The Nobel Prize in Chemistry

Wiley has published the works of 152 winners of the Nobel Prize in Chemistry starting in 1901 and most recently this year, from which a selection of content is available for free via the links below.

To discover more about all winners of the Nobel Prize in Chemistry, visit ChemistryViews’ Nobel Prize Trends page.

The Royal Swedish Academy of Sciences has awarded the 2012Nobel Prize in Chemistry jointly to Professors Robert J. Lefkowitz and Brian K. Kobilkaforstudies of G-protein–coupled receptors; both are published Wiley authorsand content will appear below shortly.

Robert J. Lefkowitz (winner 2012)

Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gβ1γ2
ActaCrystallographica Section D
Volume 59, Issue 5, May 2003, Pages: 936–939, David T. Lodowski, Jennifer F. Barnhill, Julie A. Pitcher, W. Darrell Capel, Robert J. Lefkowitz and John J. G. Tesmer
DOI: 10.1107/S0907444903002622

(Book chapter) Molecular Mechanisms of Coupling in Hormone Receptor-AdenylateCyclase Systems
Advances in Enzymology and Related Areas of Molecular Biology, Volume 53
Jeffrey M. Stadel, Andre De Lean, Robert J. Lefkowitz, Pages: 1–43, 2006
Published Online : 22 NOV 2006, DOI: 10.1002/9780470122983.ch1

(Book chapter) Historical Background and Introduction
G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24
Richard A. Bond, Robert J. Lefkowitz, Pages: 1–10, 2006
Published Online : 25 APR 2006, DOI: 10.1002/352760734X.ch1

Polymeric drugs by direct copolymerization: Polymer of β-adrenergic antagonist alprenolol and its binding to receptors and antibodies
Die MakromolekulareChemie
Volume 182, Issue 7, July 1981, Pages: 1945–1950, Josef Pitha, Jordan Zjawiony, Robert J. Lefkowitz and Marc G. Caron
Article first published online : 12 MAR 2003, DOI: 10.1002/macp.1981.021820707

β2-Adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels
The Journal of Physiology
Volume 516, Issue 1, April 1999, Pages: 19–30, R.-H. An, B. M. Heath, J. P. Higgins, W. J. Koch, R. J. Lefkowitz and R. S. Kass
DOI: 10.1111/j.1469-7793.1999.019aa.x

G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal
British Journal of Pharmacology
Volume 141, Issue 1, January 2004, Pages: 55–64, Gregory W Terman, Wenzhen Jin, Young-Pyo Cheong, Janet Lowe, Marc G Caron, Robert J Lefkowitz and Charles Chavkin
Article first published online : 2 FEB 2009, DOI: 10.1038/sj.bjp.0705595

Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase.
British Journal of Clinical Pharmacology
Volume 30, Issue S1, February 1990, Pages: 3S–12S, JL Benovic, J. Onorato, MJ Lohse, HG Dohlman, C. Staniszewski, MG Caron and RJ Lefkowitz
Article first published online : 26 JUL 2012, DOI: 10.1111/j.1365-2125.1990.tb05462.x

Cell-free Desensitization of the β-Adrenergic Receptor: Evidence that Multiple Protein Kinases Can Phosphorylate and Desensitize the Receptor
Annals of the New York Academy of Sciences
Volume 463, Issue 1, May 1986, Pages: 122–124, PONNAL NAMBI, JACK R. PETERS, DAVID R. SIBLEY and ROBERT J. LEFKOWITZ
Article first published online : 16 DEC 2006, DOI: 10.1111/j.1749-6632.1986.tb21519.x

Brian K. Kobilka (winner 2012)

Examining the efficiency of receptor/G-protein coupling with a cleavable β2-adrenoceptor-Gsα fusion protein
European Journal of Biochemistry
Volume 260, Issue 3, March 1999, Pages: 661–666, Roland Seifert, Katharina Wenzel-Seifert, UlrikGether, Van T. Lam and Brian K. Kobilka
DOI: 10.1046/j.1432-1327.1999.00161.x

Reconstitution of β2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells
European Journal of Biochemistry
Volume 255, Issue 2, July (II) 1998, Pages: 369–382, Roland Seifert, Tae Weon Lee, Van T. Lam and Brian K. Kobilka
DOI: 10.1046/j.1432-1327.1998.2550369.x

Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the β2-adrenergic receptor
Muscle & Nerve
Volume 25, Issue 5, May 2002, Pages: 729–734, Richard T. Hinkle, Karen M.B. Hodge, David B. Cody, Russell J. Sheldon, Brian K. Kobilka and Robert J. Isfort
Article first published online : 28 MAR 2002, DOI: 10.1002/mus.10092

Gene Substitution/Knockout to Delineate the Role of α2-Adrenoceptor Subtypes in Mediating Central Effects of Catecholamines and Imidazolines
Annals of the New York Academy of Sciences
Volume 881, Issue 1, June 1999, Pages: 265–271, L. HEIN, L. E. LIMBIRD, R. M. EGLEN and B. K. KOBILKA
Article first published online : 6 FEB 2006, DOI: 10.1111/j.1749-6632.1999.tb09368.x

A device for separated and reversible co-culture of cardiomyocytes
Biotechnology Progress
Volume 26, Issue 4, July/August 2010, Pages: 1164–1171, Michael Q. Chen, R. Hollis Whittington, Peter W. Day, Brian K. Kobilka, Laurent Giovangrandi and Gregory T. A. Kovacs
Article first published online : 24 MAR 2010, DOI: 10.1002/btpr.431

A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
Chemistry - A European Journal
Volume 18, Issue 31, July 27, 2012, Pages: 9485–9490, Prof. Pil Seok Chae, Prof. Søren G. F. Rasmussen, Rohini R. Rana, Kamil Gotfryd, Andrew C. Kruse, Aashish Manglik, Kyung Ho Cho, Shailika Nurva, Prof. Ulrik Gether, Prof. Lan Guan, Prof. Claus J. Loland, Dr. Bernadette Byrne, Prof. Brian K. Kobilka and Prof. Samuel H. Gellman
Article first published online : 22 JUN 2012, DOI: 10.1002/chem.201200069

Peter Debye (winner 1936)

“Polymers and Light”
Transactions of the New York Academy of Sciences
Volume 7, Issue 3 Series II, January 1945, Pages: 77–86, Peter Debye
Article first published online : 30 APR 2012, DOI: 10.1111/j.2164-0947.1945.tb00183.x

Glenn T. Seaborg (winner 1951)

Annals of the New York Academy of Sciences
Volume 216, Issue 1, May 1973, Pages: 79–88, Glenn T. Seaborg Chairman, Justin L. Bloom and Emil L. Nelson
Article first published online : 16 DEC 2006, DOI: 10.1111/j.1749-6632.1973.tb41369.x

The scientific unions: A means to achieve the goals of an international chemical society
Volume 1, Issue 4, October 1984, Pages: 187–188, Glenn T. Seaborg
Article first published online : 5 FEB 2005, DOI: 10.1002/bies.950010414

Paul J. Flory (winner 1974)

Configurational distributions for finite chain molecules
Journal of Polymer Science Part C: Polymer Symposia
Volume 25, Issue 1, 1968, Pages: 69–72, Robert L. Jernigan and Paul J. Flory
Article first published online : 8 MAR 2007, DOI: 10.1002/polc.5070250109

Rubber elasticity in the range of small uniaxial tensions and compressions. Results for poly(dimethylsiloxane)
Journal of Polymer Science: Polymer Physics Edition
Volume 16, Issue 6, June 1978, Pages: 1115–1121, Burak Erman and Paul J. Flory
Article first published online : 11 MAR 2003, DOI: 10.1002/pol.1978.180160616


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